Endocrine Abstracts

Introduction: Central diabetes insipidus (CDI) is a rare complication of acute myeloid leukemia (AML) occurring in less than 0.6% of patients. It is associated with genetic changes in chromosomes 3 and 7. CDI may precede; occur simultaneously or after the diagnosis of AML.Case report: 51-year-old man, with no relevant past medical history, began complaining with polyuria, polydipsia, weakness and weight loss in March 2015.The patient was evaluated in the...

Introduction: Type 1a Diabetes (DM1) is a challenging disease with a rising incidence (up to 40 per 100 000 in Finland and Sardinia) being less common in the African population. It is believed to have an autoimmune basis and has been associated with other autoimmune diseases namely autoimmune thyroiditis and celiac disease. Acquired hemophilia is a rare clinical entity characterized by bleeding diathesis induced by circulating inhibitors to coagulation factors (VIII ou IX) tha...

Introduction: The hyperthyroidism is a risk factor for tachyarrhythmia and dilated cardiomyopathy. Amiodarone is an effective antiarrhythmic medication, however if coexisting thyroid pathology complicates the treatment of thyroid dysfunction. It presents a case of Graves’ disease (GD) of long evolution, which illustrates the complexity of these associations. Clinical case: man, 44 years old, smoker, history of acute myocardial infarction and GD diagnosed at age 28. Has ma...

Introduction: There is a reduction of the incretin effect in patients with type 2 diabetes secondary to altered secretion of incretin hormones and/or failed of its action.Objective: To study the GLP-1 secretion pattern after an oral glucose tolerance test (OGTT) in postpartum reassessment of women with previous GDM.Materials and methods: Prospective epidemiological study of 48 women with a history of GDM. We evaluated age, history ...

Background: Optimal glucose management in older people is currently unclear. Recent guidelines recommend avoiding tight glycemic targets in elderly patients with comorbidities because intensive control is unlikely to achieve benefit and they are at higher risk of hypoglycaemia.Objective: To estimate the prevalence of potential overtreatment in older adults with diabetes mellitus and comorbidities.Design: Cross-sectional study.<...

Although, diabetes type I patients in Portugal have complete and free access to HbA1c management (via multiple daily injections) only a few percentage has been provided an insulin pump – priority is given to children and women in fertile age trying to get pregnant. By the end of 2014, 1.150 insulin pumps had already been provided by the National Program of Insulin Pumps, but at least 3.000 patients with indication for insulin pump use were in waiting list. HbA1c pre-pump ...

Background: Poorer control of risk factors for cardiovascular disease (cvd) has been reported in diabetic women compared with men.Objective: To investigate whether control of diabetes and risk factors for cvd differ between sexes in a cohort of diabetic patients monitored at an outpatient endocrinology clinic from 2004 till 2014.Design: Observational, retrospective cohort study.Patients and methods: A cohort ...

Introduction: Multiple Endocrine Neoplasia type 1 is an underdiagnosed autosomal dominant disorder, with inter and intrafamilial variability without a genotype-phenotype correlation.Case report: A young female (born in 1986) presented with galactorrhea and secondary amenorrhea in 2002, and investigation revealed a prolactinoma. Her brother (born in 1982) presenting gynecomastia and erectile dysfunction at age 21, was also diagnosed with prolactinoma. The...

Introduction: Hyperprolactinemia has been associated with several metabolic abnormalities both in glucose homeostasis, insulin sensitivity, and in lipid profile. Moreover, it has also been reported that many of them seem to improve after normalizing serum prolactin (PRL) concentrations.Objective: To study serum glucose, cholesterol and triglyceride in men with prolactinoma before and after chronic treatment with cabergoline.Patient...

Objective: To assess clinical outcome after pituitary surgery in patients nonfunctioning pituitary adenomas (NFPA) surgically treated in the past 3 decades in three tertiary referral hospitals.Methods: A multicenter retrospective study on clinical and pathological characteristics, treatment patterns, and outcome in patients with NFPA periodically followed up in specialized neuroendocrinology units who underwent surgery in the period 1982–2015 was pe...